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| Status |
Public on Dec 16, 2022 |
| Title |
IFN gamma signaling in cytotoxic T cells restricts antitumor responses by inhibiting the maintenance and clonality of intra-tumoral stem-like T cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
IFN gamma signaling in cytotoxic T cells restricts antitumor responses by inhibiting the maintenance and clonality of intra-tumoral stem-like T cells
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| Overall design |
C57Bl6 WT mice and CD8-IFNgRKO mice were engrafted with the melanoma cell line B16 expressing OVA. CD3+ CD8+ T cells were isolated by Fluorescence-activated cell sorting (FACS) from the tumor and draining lymph node after 12 days and subjected to scRNA and scTCR sequencing.
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| |
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| Contributor(s) |
Gérard A, Lau V, Koneva LA, Sansom SN |
| Citation(s) |
36658158 |
| |
| Submission date |
Dec 16, 2022 |
| Last update date |
Feb 06, 2023 |
| Contact name |
Audrey Gerard |
| E-mail(s) |
audrey.gerard@kennedy.ox.ac.uk
|
| Phone |
01865612665
|
| Organization name |
The Kennedy Institute of Rheumatology
|
| Street address |
Roosevelt Dr.
|
| City |
Oxford |
| ZIP/Postal code |
OX3 7FY |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA913000 |
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