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Series GSE220978 Query DataSets for GSE220978
Status Public on Mar 05, 2024
Title Spatial Multi-omics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Other
Summary Oral submucous fibrosis (OSF) is one of the most common precancerous malignant orders (PMO) with high rates exacerbating into oral squamous cell carcinoma (OSCC), mostly occurred in patients with chewing betel-nut habits in Southeast Asia and Pacific region. However, the spatial characteristics and heteogeneities of tumor microenvironment (TME) in OSF-associated OSCC still remains unclear. Here, we characterized the spatiotemporal changes of OSF-associated OSCC at different malignant states by performing 10x Visium Spatial Transcriptomics (ST) sequencing and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) analysis.
 
Overall design Samples from 4 OSF-associated OSCC patients were analysed by Spatial Transcriptomics sequencing (ST) and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI)
 
Contributor(s) Xiong W, Zeng Z
Citation(s) 38229179
Submission date Dec 14, 2022
Last update date Mar 06, 2024
Contact name Wei Xiong
E-mail(s) xiongwei@csu.edu.cn
Organization name Central South University
Department Cancer Research Institute
Street address 110 Xiangya Road
City Changsha
State/province Hunan
ZIP/Postal code 410078
Country China
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (4)
GSM6833484 Patient 1, ST
GSM6833485 Patient 2, ST
GSM6833486 Patient 3, ST
Relations
BioProject PRJNA912193

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE220978_RAW.tar 260.2 Mb (http)(custom) TAR (of MTX, TAR, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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