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| Status |
Public on Mar 04, 2024 |
| Title |
Mismatch repair protein MLH1 suppresses replicative stress in BRCA2 deficient breast tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the cooperative function KDM4D/NFIB/MLL1 complex in the regulation of Mirin Pretreatment, we established 10T1/2 cell lines in which each target gene has been knocked down by shRNA.
We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points.
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| |
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for mESC cells and its KD derivatives (shKDM4D, shNFIB, and shMLL1).
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| Web link |
https://www.jci.org/articles/view/173718
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| |
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| Contributor(s) |
Sharan SK, Sengodan SK |
| Citation(s) |
38271119 |
| |
| Submission date |
Dec 14, 2022 |
| Last update date |
Jun 03, 2024 |
| Contact name |
Yongmei Zhao |
| E-mail(s) |
zhaoyong@mail.nih.gov
|
| Organization name |
Frederick National Labroatory for Cancer Research
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| Department |
Biomedical Informatics and Data Science (BIDS) Directorate
|
| Street address |
Post Office Box B
|
| City |
Frederick |
| State/province |
MD |
| ZIP/Postal code |
21702 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA912195 |
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