|
| Status |
Public on Jun 23, 2011 |
| Title |
Genome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with gene expression analysis, we show PU.1 directly regulates several critical signaling pathways in erythroid cells.
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| |
|
| Overall design |
Assaying PU.1 occupancy in normal and leukemic erythroid cells
|
| |
|
| Contributor(s) |
Wontakal SN, Skoultchi AI |
| Citation(s) |
21695229, 22357756 |
| |
| Submission date |
May 21, 2010 |
| Last update date |
May 15, 2019 |
| Contact name |
Sandeep Nagaraj Wontakal |
| Organization name |
Albert Einstein College of Medicine
|
| Department |
Cell Biology
|
| Lab |
Dr. Art Skoultchi
|
| Street address |
1300 Morris Park Ave Chanin 402
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
|
| Samples (11)
|
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| This SubSeries is part of SuperSeries: |
| GSE21953 |
PU.1 in normal erythroid progenitors and erythroleukemia cells |
|
| Relations |
| SRA |
SRP002542 |
| BioProject |
PRJNA129391 |
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