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Series GSE218947 Query DataSets for GSE218947
Status Public on Nov 28, 2023
Title Influence of Sox4 on transcriptomic changes in adult hepatocytes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Recent studies have demonstrated that hepatocytes can be reprogrammed into biliary epithelial cell-like cells. An earlier work in our laboratory nominated Sox4 as an initiation factor of this reprogramming event. To investigate the effect of Sox4 on the transcriptomic changes in hepatocytes, we performed RNA-seq of Sox4-overexpressed (OE) hepatocytes.
Overall design Mice were injected with adeno-associated viruses (AAVs) packaged with mouse Sox4 (AAV8-TBG-HA-Sox4-P2A-Cre) or empty vector (AAV8-TBG-Cre). Hepatocytes were harvested 4 days post injection by a standard 2-step liberase digestion method followed by a Percoll enrichment step.
Contributor(s) Katsuda T, Sussman J, Stanger BZ
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Submission date Nov 28, 2022
Last update date Nov 28, 2023
Contact name Takeshi Katsuda
Phone +1-215-746-5559
Organization name University of Pennsylvania
Department Perelman School of Medicine
Lab Gastroenterology Division
Street address 421 Curie Blvd, BRB II/III Rm531
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM6760642 Hep_EV_1
GSM6760643 Hep_Sox4_1
GSM6760644 Hep_EV_2
This SubSeries is part of SuperSeries:
GSE221225 Sox4 in adult hepatocytes
BioProject PRJNA906174

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE218947_Median_of_ratios_normalized.txt.gz 719.5 Kb (ftp)(http) TXT
GSE218947_featureCounts_raw_count_Sox4_RNAseq.txt.gz 417.1 Kb (ftp)(http) TXT
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