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| Status |
Public on Nov 01, 2023 |
| Title |
Effect of depletion of Suv39h1 on gene expression of TGF-β stimulated mouse primary renal fibroblasts |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the the role of suv39h1 in the regulation of kidney fibrosis in vitro, we established suv39h1fl/fl mice and isolated renal fibroblasts.Fibroblasts were treated with Cre recombinant adenovirus (Ad-Cre) or GFP recombinant adenovirus(Ad-GFP) , and then TGF-β was added to the cells after starving overnight.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for Ad-Cre treated renal fibroblasts and Ad-GFP treated fibroblasts. Fibroblast activation was induced by treatment with TGF-β.
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| Contributor(s) |
Kong M, Wu X, Li N, Xu Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Nov 26, 2022 |
| Last update date |
Nov 01, 2023 |
| Contact name |
li nan |
| E-mail(s) |
linan@njmu.edu.cn
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| Organization name |
nanjing medical university
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| Department |
Basic Medicine College
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| Lab |
xu lab
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| Street address |
Longmian Avenue
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| City |
nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
231567 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| GSM6756922 |
renal fibroblasts, Ad-GFP, rep4 |
| GSM6756923 |
renal fibroblasts, Ad-Cre, rep1 |
| GSM6756924 |
renal fibroblasts, Ad-Cre, rep2 |
| GSM6756925 |
renal fibroblasts, Ad-Cre, rep3 |
| GSM6756926 |
renal fibroblasts, Ad-Cre, rep4 |
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| Relations |
| BioProject |
PRJNA905670 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE218814_GFP-vs-CRE.all.annot.txt.gz |
4.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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