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| Status |
Public on Sep 20, 2023 |
| Title |
Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Caveolae are plasma membrane invaginations found in most cells of mammals. Caveolin-1 (Cav1) encodes a major protein of the lipid rafts of these membrane structures. Cav1-null mice, though viable, show various phenotypic defects. At an early adult age, these mice show brain aging that resemble brain of one and half year old wildtype mice, and exhibit symptoms that are hallmarks of Alzheimer’s disease. It is not known if the ablation of Cav1 in these mice impacts the brain at the fetal stage that then influences brain function later in life. RNA-seq was performed to profile gene expression of fetal brain (gestation day 15) and aging brain (week 70) of Cav1 knockout mice. The data was comapred with genes expression data of fetal brain (gestation day 15) and aging brain (week 70) of wildtype mice from our earlier study.
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| Overall design |
RNA-seq was performed with fetal brain (gestation day 15) of wild-type and Cav1 knockout mice. Aging brain (week 70) from Cav1 knockout mice was also sequenced and compared with RNA-seq data of WT mice generated from our earlier study.
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| |
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| Contributor(s) |
Islam M, Behura SK |
| Citation(s) |
37720105 |
| |
| Submission date |
Oct 10, 2022 |
| Last update date |
Sep 20, 2023 |
| Contact name |
Susanta K. Behura |
| E-mail(s) |
behuras@missouri.edu
|
| Organization name |
Univeristy of Missouri
|
| Department |
Division of Animal Sciences
|
| Street address |
920 East Campus Drive
|
| City |
Columbia |
| State/province |
Missouri |
| ZIP/Postal code |
65211 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
|
| GSM6622845 |
Cav1 knockout (KO) day 15 fetal brain rep1 |
| GSM6622846 |
Cav1 knockout (KO) day 15 fetal brain rep2 |
| GSM6622847 |
Cav1 knockout (KO) day 15 fetal brain rep3 |
| GSM6622848 |
Wildtype (W) day 15 fetal brain rep1 |
| GSM6622849 |
Wildtype (W) day 15 fetal brain rep2 |
| GSM6622850 |
Wildtype (W) day 15 fetal brain rep3 |
| GSM6622851 |
Cav1 knockout (KO) week 70 aging brain rep1 |
| GSM6622852 |
Cav1 knockout (KO) week 70 aging brain rep2 |
|
| Relations |
| BioProject |
PRJNA888986 |
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