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| Status |
Public on Oct 12, 2023 |
| Title |
Myelin-Associated Oligodendrocytic Basic Protein-Dependent Myelin Repair Confers the Long-lasting Antidepressant Effect of Ketamine |
| Organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
To examine ketamine’s long-lasting effects on gene expression in the brains of mice exhibiting depression-like behaviors, we used spatial transcriptomics (ST) to analyze transcriptomics on the cortices of mice exposed to chronic social defeat stress (CSDS) and treated with ketamine.
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| Overall design |
Wild type C57 mice went through CSDS and resilient and susceptible mice were selected by social interaction test. Some susceptible mice were randomly selected and treated with ketamine. the depression-like behaviors were examined by behavioral tests and the brain samples for ST were collected 7 days after ketamine-administration.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37848708/
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| Contributor(s) |
Zu Q, Yao X, Huang C, Wang Y |
| Citation(s) |
37848708 |
| |
| Submission date |
Oct 05, 2022 |
| Last update date |
Jan 11, 2024 |
| Contact name |
Chaoli Huang |
| E-mail(s) |
chunyang@njmu.edu.cn
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| Phone |
+8613655195884
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| Organization name |
he First Affiliated Hospital of Nanjing Medical University
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| Street address |
300 Guangzhou Road
|
| City |
Nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
210003 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA887410 |
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