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Series GSE213948 Query DataSets for GSE213948
Status Public on May 30, 2023
Title Imbalanced Unfolded Protein Response Signaling Contributes to 1-Deoxysphingolipid Retinal Toxicity
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary 1-deoxysphinganine accumulation is associated with retinal toxicity. We used single nucelus and bulk sequencing to profile transcriptional remodeling following treatment with 1-dexoysphnganine in human iPSC-derived retinal organoids.
Overall design Human iPSC-derived retinal organoids were incubated with 1-dSA for either 2 days, 3 days or 4 days. At four days, organoids were treated with 1-dSA in the presence or absence of the ISRIB or AA147.
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Contributor(s) Rosarda JD, Giles S, Harkins-Perry S, Mills E, Friedlander M, Wiseman RL, Eade KT
Citation(s) 37433773
Submission date Sep 22, 2022
Last update date Jul 21, 2023
Contact name R. Luke Wiseman
Organization name The Scripps Research Institute
Department Dept. of Molecular Medicine
Street address 10550 N Torrey Pines Rd
City La Jolla
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (61)
GSM6596723 snRNAseq Day 3 control replicate 1
GSM6596724 snRNAseq Day 3 control replicate 2
GSM6596725 snRNAseq Day 3 1-dSA treated replicate 1
BioProject PRJNA883248

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE213948_Day_2_RawGeneCounts.csv.gz 1.1 Mb (ftp)(http) CSV
GSE213948_Day_3_RawGeneCounts.csv.gz 1.0 Mb (ftp)(http) CSV
GSE213948_Day_4_AA147_Set_RawGeneCounts.csv.gz 684.5 Kb (ftp)(http) CSV
GSE213948_Day_4_ISRIB_Set_RawGeneCounts.csv.gz 1.2 Mb (ftp)(http) CSV
GSE213948_RAW.tar 586.3 Mb (http)(custom) TAR (of TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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