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Series GSE213666 Query DataSets for GSE213666
Status Public on Jan 13, 2023
Title Multi-omics profiling visualizes dynamics of cardiac development and functions
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The function and phenotype transitions of heart may be specific to one or other chamber. To provide the omics data sets from chambers separately, we conducted spatial transcriptomics of E10.5 hearts to identify unique gene profiles that correspond to distinct anatomical regions in early cardiac development. We obtained curated expression data consisting of 6,798 genes across 332 individual capture spots. We then performed differential gene expression (DGE) analysis between anatomical regions and gene set enrichment analysis of each cluster’s upregulated genes to characterize identified clusters in early cardiogenesis.
 
Overall design 10X Visium was used to create a transcriptomic atlas of mouse embryonic day 10.5 heart.
 
Contributor(s) Gu Y, Zhou Y, Gao J, Xu J
Citation(s) 36577384
Submission date Sep 19, 2022
Last update date Jan 15, 2023
Contact name Jimiao Gao
E-mail(s) Gaojimiao_Gloria@stu.njmu.edu.cn
Phone +8618061621262
Organization name Nanjing Medical University
Street address 101Longmian Avenue, Jiangning District, Nanjing 211166, P.R. China
City Nanjing
ZIP/Postal code 211166
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (1)
GSM6591749 heart_E10.5_WT
Relations
BioProject PRJNA882046

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE213666_RAW.tar 505.8 Mb (http)(custom) TAR (of TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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