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| Status |
Public on Apr 17, 2023 |
| Title |
Spatial transcriptomics of the mouse brain across three age groups |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Aging is a key driver of cognitive decline and the predominant risk factor for several neurodegenerative diseases. Recent behavioral studies as well as structural and functional MRI data suggest that aging does not impact the brain in a uniform manner but follows region- and age-specific trajectories. Yet so far, quantitative analyses of the molecular dynamics in the aging brain have been limited to few regions at low temporal resolution. Here we use the 10X Visium platform to perform spatial transcriptomics (Spatial-seq) of equivalent coronal sections of the mouse brain at young (6 months), middle (18 months) and old (21 months) age.
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| Overall design |
Spatial RNA-seq of coronal brain sections from young, middle and old mice using 10x Genomics Visium for OCT embedded tissue (v3').
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| Contributor(s) |
Hahn O, Foltz AG, Atkins M, Kedir B, Moran-Losada P, Munson C, Guldner I, Kern F, Pálovics R, Lu N, Lehallier B, Keller A, Wyss-Coray T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 08, 2022 |
| Last update date |
Apr 22, 2023 |
| Contact name |
Oliver Hahn |
| E-mail(s) |
ohahn@calicolabs.com
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| Organization name |
Calico Life Sciences, LLC
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| Lab |
Oliver Hahn
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| Street address |
1170 Veterans Blvd
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| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA878093 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE212903_RAW.tar |
1.3 Gb |
(http)(custom) |
TAR (of MTX, TIFF, TSV) |
| GSE212903_spatial.tar.gz |
60.4 Mb |
(ftp)(http) |
TAR |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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