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Series GSE212903 Query DataSets for GSE212903
Status Public on Apr 17, 2023
Title Spatial transcriptomics of the mouse brain across three age groups
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Aging is a key driver of cognitive decline and the predominant risk factor for several neurodegenerative diseases. Recent behavioral studies as well as structural and functional MRI data suggest that aging does not impact the brain in a uniform manner but follows region- and age-specific trajectories. Yet so far, quantitative analyses of the molecular dynamics in the aging brain have been limited to few regions at low temporal resolution. Here we use the 10X Visium platform to perform spatial transcriptomics (Spatial-seq) of equivalent coronal sections of the mouse brain at young (6 months), middle (18 months) and old (21 months) age.
Overall design Spatial RNA-seq of coronal brain sections from young, middle and old mice using 10x Genomics Visium for OCT embedded tissue (v3').
Contributor(s) Hahn O, Foltz AG, Atkins M, Kedir B, Moran-Losada P, Munson C, Guldner I, Kern F, Pálovics R, Lu N, Lehallier B, Keller A, Wyss-Coray T
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Submission date Sep 08, 2022
Last update date Apr 22, 2023
Contact name Oliver Hahn
Organization name Calico Life Sciences, LLC
Lab Oliver Hahn
Street address 1170 Veterans Blvd
City South San Francisco
State/province CA
ZIP/Postal code 94080
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM6560897 Young Replicate 1 Slide 1
GSM6560898 Middle Replicate 1 Slide 1
GSM6560899 Old Replicate 1 Slide 1
BioProject PRJNA878093

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Supplementary file Size Download File type/resource
GSE212903_RAW.tar 1.3 Gb (http)(custom) TAR (of MTX, TIFF, TSV)
GSE212903_spatial.tar.gz 60.4 Mb (ftp)(http) TAR
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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