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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 10, 2023 |
| Title |
Effect of depletion of GPR30 on gene expression in female C57BL/6J mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To test the cell-specific function of GPR30 in learning and memory, we generated global GPR30 knockout (KO) mice (Δ3102), astrocyte-specific GPR30 KO (AG-KO) mice and neuron-specific GPR30 KO (NG-KO) mice. We found that GPR30 in astrocytes but not neurons is required to maintain normal learning and memory. To further elucidate the signaling pathway by which GPR30 plays a role in astrocyte function, high-throughput RNA sequencing of hippocampal tissues from Δ3102, AG-KO, and NG-KO mice was performed.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for WT, Δ3102, AG-KO, and NG-KO mice
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| Contributor(s) |
Wang X, Liu S |
| Citation(s) |
37712419 |
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| Submission date |
Sep 08, 2022 |
| Last update date |
Sep 21, 2023 |
| Contact name |
Xin-shang Wang |
| E-mail(s) |
xinshang@fmmu.edu.cn
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| Phone |
15596812617
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| Organization name |
Fourth Military Medical University
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| Street address |
Changle road No.169
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| City |
xi'an |
| State/province |
China |
| ZIP/Postal code |
710032 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (14)
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| GSM6560617 |
Hippocampus, Δ3102, rep1 |
| GSM6560618 |
Hippocampus, Δ3102, rep2 |
| GSM6560619 |
Hippocampus, Δ3102, rep3 |
| GSM6560620 |
Hippocampus, AG-KO, rep1 |
| GSM6560621 |
Hippocampus, AG-KO, rep2 |
| GSM6560622 |
Hippocampus, AG-KO, rep3 |
| GSM6560623 |
Hippocampus, AG-KO, rep4 |
| GSM6560624 |
Hippocampus, NG-KO, rep1 |
| GSM6560625 |
Hippocampus, NG-KO, rep2 |
| GSM6560626 |
Hippocampus, NG-KO, rep3 |
| GSM6560627 |
Hippocampus, NG-KO, rep4 |
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| Relations |
| BioProject |
PRJNA877835 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE212893_genes_fpkm_expression.txt.gz |
8.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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