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Series GSE21228 Query DataSets for GSE21228
Status Public on Mar 25, 2011
Title Identification of SNP candidates associated with chemo-responsiveness in colorectal cancer patients
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Summary Response rates of 118 colorectal cancer patients to regiments were evaluated by histoculture drug response assay. Affymetrix SNP 6.0 chips were used to determine genotypes of the same colorectal cancer patients. SNPs associated with chemosensitivity to treatment regiments were identified by genome-wide association study.
AV: avastin (Bevacizumab), ER: Erbitux (Cetuximab), FXA: bevacizumab + FOLFOX, FXE: Cetuximab + FOLFOX , FRA: Bevacizumab + FOLFIRI, FRE: Cetuximab + FOLFIRI; Numbers (0-100) represent responsiveness to the given drug regimens; the larger, the better responsive to given regimens
Overall design SNP association with drug responsiveness
Contributor(s) Kim J, Jeon YJ, Ju HS, Kim HJ, Kang TW, Kim SY, Kim YS
Citation(s) 21239504
Submission date Apr 06, 2010
Last update date Nov 27, 2018
Contact name Seon-Young Kim
Phone 82-42-879-8116
Organization name Korea Research Institute of Bioscience and Biotechnology
Department Genome Research Center
Lab Human Genomics
Street address 52 Eoeun-dong, Yuseong-gu
City Daejon
ZIP/Postal code 305333
Country South Korea
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (118)
GSM530679 Blood from colorectal cancer patient HRCRC2001
GSM530680 Blood from colorectal cancer patient HRCRC2002
GSM530681 Blood from colorectal cancer patient HRCRC2003
BioProject PRJNA126493

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21228_RAW.tar 5.0 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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