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Series GSE211514 Query DataSets for GSE211514
Status Public on Aug 22, 2022
Title RNA data of NCI-H446 tumours treated with ERY974 and/or cisplatin in huNOG mice
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We found that ERY974 shows only moderate antitumor efficacy in NCI-H446 non-inflamed tumor in huNOG mice. We also observed that ERY974 + cisplatin increases antitumour efficacy in non-inflamed NCI-H446 tumours.
To identify a mechanism of combination effect, we compared RNA expression of NCI-H446 tumors treated with ERY974, cisplatin, or combination.
Overall design Comparative gene expression profiling analysis of RNA-seq data for tumors treated with ERY974, cisplatin, or combination in huNOG model.
Contributor(s) Sano Y, Nishito Y, Azuma Y, Kinoshita Y, Tsunenari T, Ishiguro T
Citation(s) 36071036
Submission date Aug 17, 2022
Last update date Nov 21, 2022
Contact name YUJI SANO
Phone +810467476241
Organization name Chugai Pharmaceutical Co., Ltd
Street address 200
City Kajiwara
State/province Kamakura
ZIP/Postal code 247-8530
Country Japan
Platforms (1)
GPL22245 Illumina HiSeq 2500 (Homo sapiens; Mus musculus)
Samples (36)
GSM6474960 NCI-H446 vehicle-1
GSM6474961 NCI-H446 vehicle-2
GSM6474962 NCI-H446 vehicle-3
BioProject PRJNA870586

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Supplementary file Size Download File type/resource
GSE211514_RNAseq_ERY974_cisplatin_NCI_H446_huNOG.xlsx 5.4 Mb (ftp)(http) XLSX
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