GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE211512 Query DataSets for GSE211512
Status Public on Aug 22, 2022
Title RNA data of baseline and ERY974-treated tumour samples for various xenograft tumors (PC10, NCI-H446, MKN45, and MKN74).
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary GPC3 expression is one of the important predictive marker of ERY974. However, we found that efficacy of ERY974 is sometimes different in tumors with the similar GPC3 expression.
To identify a predictive biomrker of ERY974, we compared baseline RNA expression of tumors in which ERY974 shows moderate efficacy, and/or achives the regression with similar GPC3 expression.
Overall design Comparative gene expression profiling analysis of RNA-seq data for tumors of PC10 (ERY974 shows regression/GPC3 high), NCI-H446 (ERY974 shows moderate efficacy/GPC3 high), MKN74 (ERY974 shows regression/GPC3 low), and MKN45(ERY974 shows moderate efficacy/GPC3 low).
Contributor(s) Sano Y, Nishito Y, Azuma Y, Kinoshita Y, Tsunenari T, Ishiguro T
Citation(s) 36071036
Submission date Aug 17, 2022
Last update date Nov 21, 2022
Contact name YUJI SANO
Phone +810467476241
Organization name Chugai Pharmaceutical Co., Ltd
Street address 200
City Kajiwara
State/province Kamakura
ZIP/Postal code 247-8530
Country Japan
Platforms (1)
GPL22245 Illumina HiSeq 2500 (Homo sapiens; Mus musculus)
Samples (24)
GSM6474927 PC10 vehicle 1
GSM6474928 PC10 vehicle 2
GSM6474929 PC10 vehicle 3
BioProject PRJNA870580

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE211512_RNAseq_ERY974_PC10_NCI_H446_MKN45_MKN74_huNOG.xlsx 7.5 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap