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Series GSE211374 Query DataSets for GSE211374
Status Public on Aug 21, 2022
Title RNA data of NCI-H446 tumours treated with ERY974 and/or paclitaxel in huNOG mice.
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We found that ERY974 shows only moderate antitumor efficacy in NCI-H446 non-inflamed tumor in huNOG mice. We also observed that ERY974 + paclitaxel increases antitumour efficacy in non-inflamed NCI-H446 tumours.
To identify a mechanism of combination effect, we compared RNA expression of NCI-H446 tumors treated with ERY974, cisplatin, or combination.
Overall design Comparative gene expression profiling analysis of RNA-seq data for tumors treated with ERY974, paclitaxel, or combination in huNOG model.
Contributor(s) Sano Y, Nishito Y, Azuma Y, Kinoshita Y, Tsunenari T, Ishiguro T
Citation(s) 36071036
Submission date Aug 16, 2022
Last update date Nov 21, 2022
Contact name YUJI SANO
Phone +810467476241
Organization name Chugai Pharmaceutical Co., Ltd
Street address 200
City Kajiwara
State/province Kamakura
ZIP/Postal code 247-8530
Country Japan
Platforms (1)
GPL22245 Illumina HiSeq 2500 (Homo sapiens; Mus musculus)
Samples (38)
GSM6467663 NCI-H446_vehicle_1
GSM6467664 NCI-H446_vehicle_2
GSM6467665 NCI-H446_vehicle_3
BioProject PRJNA870063

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE211374_RNAseq_ERY974_paclitaxel_NCI_H446_huNOG.xlsx 5.8 Mb (ftp)(http) XLSX
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Processed data are available on Series record

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