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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 17, 2022 |
| Title |
Single cell ATAC-seq analysis of the kidney in a murine endotoxemia model |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To investigate chromatin accessibility changes after endotoxin exposure in the mouse kidney, single-cell ATACseq was performed (10X Genomics). Low dose endotoxin (0.25 mg/kg) was used to examine the renoprotective effects of endotoxin preconditioning.
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| Overall design |
C57BL/6J male mice (8-10 weeks of age) were subjected to the following condtions: 1) untreated control, 2) 0.25 mg/kg LPS for 4 hrs, 3) 0.25 mg/kg LPS for 24 hrs, 4) 0.25 mg/kg LPS followed 24 hrs later by 5 mg/kg LPS for 24 hrs. 5) 5 mg/kg LPS for 16 hrs.
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| Contributor(s) |
Hato T |
| Citation(s) |
36283811 |
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| Submission date |
Aug 10, 2022 |
| Last update date |
Nov 16, 2022 |
| Contact name |
Takashi Hato |
| E-mail(s) |
thato@iu.edu
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| Phone |
317-278-4286
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| Organization name |
Indiana University
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| Department |
Medicine
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| Street address |
950 W. Walnut St. R2 202
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| City |
Indianapolis |
| State/province |
IN |
| ZIP/Postal code |
46202 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA868340 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE210938_RAW.tar |
26.3 Gb |
(http)(custom) |
TAR (of BED, CLOUPE, H5, TBI, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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