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Series GSE210555 Query DataSets for GSE210555
Status Public on May 21, 2024
Title Impaired signaling pathways on Berardinelli–Seip congenital lipodystrophy macrophages during Leishmania infantum infection
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This was an in vitro experimental study of monocytes-derived macrophages from blood samples of BSCL individuals (type I - AGPAT2, type II - BSCL2, and heterozygous - BSCL2), and healthy controls (WT). Samples were infected with L. infantum. In the control group, there are monocytes-derived macrophages from individuals WT with and without a history of visceral leishmaniasis (VL). RNA-seq was done to identify the different group responses to the infection.
 
Overall design Monocyte-derived macrophage samples from BSCL individuals (type I and II, and type II heterozygous) and wild type (WT with and without an LV history) were infected with L. infantum. Both infected and non-infected mRNA samples were sequenced, each containing three experimental replicates (with the exception of participant 6, who has only an experimental duplicate in the infected sample).
Web link https://pubmed.ncbi.nlm.nih.gov/38755198/
 
Contributor(s) Nogueira VB, Mendes-Aguiar CO, Lima JG, Jeronimo SB
Citation(s) 38755198
Submission date Aug 04, 2022
Last update date May 21, 2024
Contact name Selma MB Jeronimo
Organization name Federal University of Rio Grande do Norte (UFRN)
Department Tropical Medicine Institute (IMT-RN)
Street address 655 Av Passeio dos Girassois, Capim Macio
City Natal
State/province Rio Grande do Norte
ZIP/Postal code 59078190
Country Brazil
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (36)
GSM6432399 RNA-seq: Infected AGPAT2mut 1
GSM6432400 RNA-seq: Non-Infected AGPAT2mut 1
GSM6432401 RNA-seq: Infected AGPAT2mut 2
Relations
BioProject PRJNA866148

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE210555_gene_counts_matrix.txt.gz 2.3 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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