NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE206743 Query DataSets for GSE206743
Status Public on Oct 15, 2022
Title Effect of TGFB1 and Smad3 deficiency on doxorubicin cardiotoxity
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To examine the role of the TGF-beta/Smad3 pathway in cardiac damage by doxorubicin, we performed comparitive RNA sequencing analysis of human cardiac endothelial cells transfected with Smad3 shRNA
 
Overall design To determine if the endothelial response to TGF-beta1 was enhanced by pretreatment with doxorubicin, human cardiac endothelial cells were pretreated with doxorubicin and subsequently exposed to TGF-beta1 to examine activation of the canonical pathway.
 
Contributor(s) Konorev EA, Shortt K, Heruth DP
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jun 22, 2022
Last update date Oct 15, 2022
Contact name Eugene Konorev
E-mail(s) EKonorev@kansascity.edu
Phone 816-654-7639
Organization name Kansas City University
Department Basic Sciences
Street address 1750 Independence Ave
City Kansas City
State/province MISSOURI
ZIP/Postal code 64106
Country USA
 
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (4)
GSM6261741 scramble shRNA +TGFB1
GSM6261742 scramble shRNA +TGFB1 + DOX
GSM6261743 Smad3 shRNA + TGFB1
Relations
BioProject PRJNA851904

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE206743_EK176_FPKMs.xlsx 3.1 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap