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Series GSE20565 Query DataSets for GSE20565
Status Public on Apr 14, 2010
Title Primary and secondary ovarian tumors
Organism Homo sapiens
Experiment type Expression profiling by array
SNP genotyping by SNP array
Genome variation profiling by SNP array
Summary The distinction between primary and secondary ovarian tumors may be challenging for pathologists.
We performed transcriptomic analysis in order to discriminate between primary ovarian tumors and ovarian metastases after primary breast cancer.
We performed genomic analysis on tumor paired samples (breast/ovary) in order to know if genomic profiles could help for the discrimination of primary ovarian tumors and ovarian metastases after primary breast cancer.
 
Overall design 1) Transcriptomic profiling: The transcriptomes of ovarian carcinomas from patients with previous history of breast cancer, and for which the primary or secondary status was uncertain, were analyzed using Affymetrix U133plus2 Arrays. A hierarchical clustering of these samples was performed, combined with a dataset of well-identified primary and secondary ovarian tumors.
2) Genomic profiling: Sixteen paired breast-ovary tumors from patients with a former dignosis of breast cancer were collected. The genomic profiles of paired tumors were analyzed using Affymetrix 50k_Xba or SNP6 arrays.
 
Contributor(s) Meyniel J, Cottu PH, Decraene C, Stern M, Couturier J, Lebigot I, Nicolas A, Weber N, Fourchotte V, Alran S, Rapinat A, Gentien D, Roman-Roman S, Mignot L, Sastre-Garau X
Citation(s) 20492709, 37163587
Submission date Mar 01, 2010
Last update date Aug 04, 2023
Contact name Jean-Philippe MEYNIEL
E-mail(s) jean-philippe.meyniel@curie.fr
Phone +33153194126
Fax +33153194130
Organization name Institut Curie
Department Translational Research Dept
Street address 26, rue d'Ulm
City PARIS
ZIP/Postal code 75248
Country France
 
Platforms (3)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL2005 [Mapping50K_Xba240] Affymetrix Human Mapping 50K Xba240 SNP Array
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (172)
GSM516678 Ovarian carcinoma_OC01_ARN0001 [HG-U133_Plus_2]
GSM516679 Ovarian carcinoma_OC01_ARN0002 [HG-U133_Plus_2]
GSM516680 Ovarian carcinoma_OC01_ARN0004 [HG-U133_Plus_2]
Relations
BioProject PRJNA125217

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE20565_RAW.tar 1.1 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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