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Series GSE204835 Query DataSets for GSE204835
Status Public on May 30, 2022
Title Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The pathogenesis of preeclampsia superimposed on chronic hypertension is poorly understood relative to preeclampsia occurring in pregnant people without chronic hypertension. Placental transcriptomes in pregnancies complicated by de novo preeclampsia and superimposed preeclampsia have not been previously compared.
 
Overall design The goal of this study is to investigate the transcriptomes of placentas from different types of hypertensive pregnancies.
We identified pregnant people in the University of Michigan Biorepository for Understanding Maternal and Pediatric Health with hypertensive disorders affecting singleton, euploid gestations (N=36) along with non-hypertensive control subjects (N=12). Subjects were grouped as: (1) normotensive (N=12), (2) chronic hypertensive (N=13), (3) preterm preeclampsia with severe features (N=5), (4) term preeclampsia with severe features (N=11), (5) preterm superimposed preeclampsia (N=3), or (6) term superimposed preeclampsia (N=4). Bulk RNA sequencing of paraffin-embedded placental tissue was performed.
 
Contributor(s) Hesson A, Langen E, Olesya P, Gudjonsson J, Ganesh S
Citation(s) 37131171
Submission date May 25, 2022
Last update date Aug 02, 2023
Contact name Ashley Hesson
E-mail(s) ahesson@med.umich.edu
Phone (716) 348-9693
Organization name University of Michigan
Street address 1500 E Medical Center Dr.
City Ann Arbor
State/province MI
ZIP/Postal code 48109
Country USA
 
Platforms (1)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (48)
GSM6198397 Human_paraffin-embedded_placental_tissue_Sample 2
GSM6198398 Human_paraffin-embedded_placental_tissue_Sample 3
GSM6198399 Human_paraffin-embedded_placental_tissue_Sample 4
Relations
BioProject PRJNA842427

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE204835_Human_paraffin-embedded_placental_tissue_counts.csv.gz 809.9 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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