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Series GSE204693 Query DataSets for GSE204693
Status Public on Oct 17, 2023
Title scGEX/scTCR-Seq of CD44+ cytotoxic T cells in LCMV-infected Wildtype and Il1rl1-ExAB-/- mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To study the effect of IL-33 sensing on CD8 T cell differentiation during acute infection with lymphocytic choriomeningitis virus (LCMV), activated CD44+ CTLs were flowcytometrically sorted from infected C57BL/6 wildtype and Il1rl1 gene-targeted mice (Il1rl1-ExAB-/-) and subjected to combined single-cell gene expression and single cell TCR-Seq analysis.
Overall design Comparative gene expression profiling analysis of the effects of IL-33 on CTLs, Th1 and Th2 cells using RNA-Seq and single-cell RNA-Seq of WT- and Il1rl1-ExAB-KO CTLs after an acute LCMV infection.
Contributor(s) Brunner TM, Serve SG, Marx A, Dzamukova M, Duran N, Saikali P, Kommer C, Heinrich F, Durek P, Heinz GA, Höfer T, Mashreghi M, Pinschewer DD, Kühn R, Löhning M
Citation(s) 38172258
Submission date May 24, 2022
Last update date Feb 14, 2024
Contact name Pawel Durek
Organization name Deutsches Rheuma-Forschungszentrum
Street address Charitéplatz 1
City Berlin
ZIP/Postal code 10117
Country Germany
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL30172 NextSeq 2000 (Mus musculus)
Samples (6)
GSM6185954 Il1rl1-ExAB-/- (GEX)
GSM6185955 WT (GEX)
GSM6185956 Il1rl1-ExAB-/- (ADT, HTO)
This SubSeries is part of SuperSeries:
GSE204695 A type 1 immunity-restricted promoter of the IL-33 receptor gene drives antiviral T cell responses
BioProject PRJNA841968

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE204693_AB_filtered_contig.fasta.gz 642.5 Kb (ftp)(http) FASTA
GSE204693_AB_filtered_contig_annotations.csv.gz 308.5 Kb (ftp)(http) CSV
GSE204693_AB_filtered_feature_bc_matrix.h5 15.6 Mb (ftp)(http) H5
GSE204693_WT_filtered_contig.fasta.gz 322.4 Kb (ftp)(http) FASTA
GSE204693_WT_filtered_contig_annotations.csv.gz 153.8 Kb (ftp)(http) CSV
GSE204693_WT_filtered_feature_bc_matrix.h5 6.2 Mb (ftp)(http) H5
GSE204693_feature_reference.csv.gz 486 b (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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