|
| Status |
Public on Sep 26, 2022 |
| Title |
INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
Spatial Transcriptomics (Visium) of 12 coronal brain sections from 6 months old female Inpp5dfl/fl/Cx3cr1CreER/+ crossed to APPKM670/671NL/PSEN1Δexon9 (PSAPP) mice and treated with either cornoil or tamoxifen (75 mg/kg) at 3 months of age for 5 consecutive days
|
| |
|
| Overall design |
Spatial Transcriptomics of Inpp5dfl/fl/Cx3cr1CreER/+ crossed to APPKM670/671NL/PSEN1Δexon9 (PSAPP) mice to study the transcriptomics, brain-region resolved effect of removing Inpp5d from microglia in an animal model of Alzheimer's disease
|
| |
|
| Contributor(s) |
Hasel P, Liddelow SA, Castranio EL, Ehrlich ME |
| Citation(s) |
36448627 |
| |
| Submission date |
May 20, 2022 |
| Last update date |
Dec 09, 2022 |
| Contact name |
Philip Hasel |
| E-mail(s) |
philip.hasel@nyulangone.org
|
| Organization name |
NYU Langone Medical Centre
|
| Street address |
435 E 30th St
|
| City |
New York |
| ZIP/Postal code |
10016 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA839942 |
Less...
More...