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| Status |
Public on Apr 30, 2022 |
| Title |
Dissecting genetic components associated with eye disease using integrative genomic analysis [Capture HiC] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
GWAS studies have revealed thousands of variants strongly associated with AMD, yet connecting these variants to their cognate genes has not been explored. In this study we fine-mapped AMD risk loci and examined long-range cis chromatin interactions at essential genes of RPE function and disease-associated variants in iPSC-induced retinal pigmented epithelium (RPE) and primary RPE.
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| |
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| Overall design |
Capture HiC from iPSCs (2 replicates), iPSC-induced RPE (2 replicates).
|
| |
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| Contributor(s) |
Jamieson K, Shen Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 27, 2022 |
| Last update date |
Apr 30, 2022 |
| Contact name |
Kirsty Jamieson |
| E-mail(s) |
kirstyjamieson@gmail.com
|
| Organization name |
University of California
|
| Street address |
400 Parnassus Ave
|
| City |
San Francisco |
| ZIP/Postal code |
94143 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (4)
|
| GSM6069388 |
Capture HiC, iPSC-induced RPE, biol rep1 |
| GSM6069389 |
Capture HiC, iPSC-induced RPE, biol rep2 |
| GSM6069390 |
Capture HiC, primary RPE, biol rep1 |
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| This SubSeries is part of SuperSeries: |
| GSE201681 |
Dissecting genetic components associated with eye disease using integrative genomic analysis |
|
| Relations |
| BioProject |
PRJNA832670 |
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