|
| Status |
Public on Aug 03, 2022 |
| Title |
A novel class of early responder T cells are indispensable for neuroprotection and functional recovery after ischemic stroke |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report that CD8+CD122+CD49dlow regulatory-like T cells (CD8+TRLs) are among the earliest lymphocytes to infiltrate mouse brain after ischemic stroke, temper inflammation, and confer neuroprotection.
|
| |
|
| Overall design |
CD8+CD122+CD49dlow TRLs were FACS-isolated directly into a plate with lysis buffer from the brain and blood of young male mice 3 days after transient (60 min) middle cerebral artery occlusion (tMCAO) or blood of sham operation and subjected to RNA-sequencing analysis.
|
| |
|
| Contributor(s) |
Chen J, Hu X |
| Citation(s) |
35912857 |
| |
| Submission date |
Apr 19, 2022 |
| Last update date |
Aug 03, 2022 |
| Contact name |
Xiaoming Hu |
| E-mail(s) |
hux2@upmc.edu
|
| Organization name |
University of Pittsburgh
|
| Department |
Neurology
|
| Street address |
200 lothrop street
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA828160 |
Less...
More...