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| Status |
Public on Jan 03, 2023 |
| Title |
Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO1_and PPO1_Cells_RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig2 and Olig1 positive cells in glioma pathogenesis.
We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 PPO2, 4 PPO1 and 2 OPN cell lines.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for PPO1 & PPO2 cell lines with Oligodendrocyte progenitor Cells and neural stem cells tissue from publically available datasets. And also explore transcriptomic changes of Nf1 and Trp53 knocl out in OPC with PPO1
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| |
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| Contributor(s) |
Lu QR, Verma RK, Xin D |
| Citation(s) |
36634201 |
| |
| Submission date |
Apr 15, 2022 |
| Last update date |
Jun 29, 2023 |
| Contact name |
Richard Q. Lu |
| E-mail(s) |
richard.lu@cchmc.org, vermare@mail.uc.edu
|
| Phone |
15133941514
|
| Organization name |
Cincinnati Childrens Hosp Med Ctrl
|
| Department |
CBDI
|
| Lab |
Lu Lab, T6 525
|
| Street address |
3333 Burnet Avenue
|
| City |
CINCINNATI |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE200892 |
Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities |
|
| Relations |
| BioProject |
PRJNA827149 |
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