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| Status |
Public on Dec 01, 2011 |
| Title |
p27 binds to promoters of multiple genes leading to their repression |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
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| Summary |
The role of the cyclin-cdk inhibitor p27 in tumorigenesis is still a controversial matter. We demonstrate here that p27 negatively regulates transcription of a number of genes (p27-target genes) involved in key cellular functions as RNA processing, translation, respiration and cell proliferation.
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| Overall design |
Crosslinked chromatin from quiescent NIH3T3 cells was sonicated, incubated overnight with the rabbit anti-p27 and IgG antibodies as control
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| Contributor(s) |
Pippa R, Espinosa L, Gundem G, García-Escudero R, Domínguez A, Sainz C, Besson A, Pujol MJ, López-Bigas N, Paramio JM, Bachs O |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 27, 2010 |
| Last update date |
Dec 06, 2012 |
| Contact name |
oriol bachs |
| E-mail(s) |
obachs@ub.edu, raffaellapippa@ub.edu
|
| Phone |
636574156
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| Fax |
0034-934021907
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| Organization name |
University of Barcelona
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| Department |
Cell Biology, Immunology and Neurosciences
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| Street address |
Casanova 143
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| City |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
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| Platforms (2) |
| GPL4128 |
Agilent-014716 Mouse Promoter ChIP-on-Chip Set 244K, Microarray 1 of 2 (G4490A) (Feature Number version) |
| GPL4129 |
Agilent-014717 Mouse Promoter ChIP-on-Chip Set 244K, Microarray 2 of 2 (G4490A) (Feature Number version) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE20069 |
p27Kip1 regulates transcription of genes involved in tumorigenesis |
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| Relations |
| BioProject |
PRJNA129795 |
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