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| Status |
Public on Jun 13, 2022 |
| Title |
RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The retinoblastoma tumor suppressor (RB1) plays a critical role in coordinating multiple pathways that impact on tumor initiation, disease progression, and therapeutic responses. Here we interrogated the effect of cIAP inhibitor, birinapant in two different isogenic ER+ breast cancer models. Using MCF7-WT and MCF7-RB-del cell lines we investigated the differential gene expression pattern that link the effect of CIAP inhibition and RB dependency .
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| Overall design |
MCF7-WT and MCF7-RB-del cells were treated with birinapant at a concentration of 500 nM for 48 hours. RNA was extracted using Quiagen Rneasy plus kit.
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| Citation(s) |
35676324 |
| |
| Submission date |
Apr 01, 2022 |
| Last update date |
Sep 12, 2022 |
| Contact name |
Jianxin Wang |
| Organization name |
Roswell Park Comprehensive Cancer Center
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| Department |
Molecular and Cellular Biology
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| Street address |
665 Elm Street
|
| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14203 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA822087 |
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