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Status |
Public on May 08, 2024 |
Title |
An epigenetic gene signature underlies phenotype switching in early stage melanomas [SKMel147] |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
A 122-epigenetic gene signature distinguished low- versus high-risk early stage melanomas. We sought to validate the signature, examined clinical correlates in a cohort of primary melanomas of the skin, and studied the underlying transcriptomic aberrations and changes in chromatin in cell lines representing these two groups.
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Overall design |
mRNA profiles of SKMel147 metatastic human melanoma cell lines with siRNA scramble (n=3) and were generated by deep sequencing, in triplicate, using Illumina NextSeq500.
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Contributor(s) |
Mendelson K, Martin T |
Citation(s) |
38319712 |
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Submission date |
Mar 11, 2022 |
Last update date |
May 09, 2024 |
Contact name |
Tiphaine Christiane Martin |
E-mail(s) |
tiphaine.martin@mssm.edu
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Phone |
2128248403
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Organization name |
Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
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Department |
Oncological Sciences
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Lab |
Parsons
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Street address |
1470 Madison Ave
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City |
New York |
State/province |
75459 |
ZIP/Postal code |
10029 |
Country |
USA |
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Platforms (1) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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Samples (6)
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This SubSeries is part of SuperSeries: |
GSE198432 |
An epigenetic gene signature underlies phenotype switching in early stage melanomas. |
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Relations |
BioProject |
PRJNA815291 |