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Status |
Public on Oct 26, 2022 |
Title |
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis [scRNA-seq] |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
In this study, using the mouse molar as a model, we took advantage of single-cell transcriptome profiling, lineage tracing and transgenic mouse models to interrogate the cellular heterogeneity and gene regulatory networks (GRNs) of postmigratory CNCCs.In this study, we have put together a dynamic spatiotemporal single-cell regulatory atlas and revealed the landscape of transcriptional heterogeneity and defined the cellular domains during the progression of cranial neural crest cell (CNCC)-derived dental lineage diversification. Importantly, we identified cell type-specific gene regulatory networks (GRNs) during CNCC-derived dental lineage development.
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Overall design |
Single-nuclei transcriptomes were obtained from trigemial ganglion of one-month-old mice
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Contributor(s) |
Pei F |
Citation(s) |
36670126 |
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Submission date |
Mar 02, 2022 |
Last update date |
Feb 08, 2023 |
Contact name |
Fei Pei |
E-mail(s) |
fp_191@usc.edu
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Phone |
2132454762
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Organization name |
USC
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Street address |
2250 Alcazar St
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City |
Los Angeles |
State/province |
CA |
ZIP/Postal code |
90033 |
Country |
USA |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (1) |
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This SubSeries is part of SuperSeries: |
GSE197787 |
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. |
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Relations |
BioProject |
PRJNA812042 |