 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Apr 20, 2023 |
| Title |
A single-cell atlas of the tumor, stromal and immune microenvironments in pancreatic cancer liver metastasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignant tumors all over the world, with a 5-year survival rate of less than 10%1,2. Usually diagnosed at an advanced stage, PDAC is highly resistant to current therapies, partly due to an extremely high rate of distant metastasis (>80%) at first diagnosis. The liver is the most frequent site of distant metastases for PDAC. Current therapeutic options for PDAC patients with liver metastasis are extremely limited3. Thus, understanding the molecular mechanisms underlying hepatic metastasis of PDAC is urgently needed to help us develop more effective treatments and improve survival for these patients with advanced disease.
|
| |
|
| Overall design |
Four primary untreated pancreatic ductal adenocarcinoma (PDAC) tumor, three hepatic metastasis along with one adjacent normal tissues were included in this cohort.
Sample codes:
ZC: normal pancreatic tissue
YF: pancreatic tumors
ZY: hepatic metastases
Raw scRNA-seq data from this study have been deposited in the Genome Sequence Archive for Human (GSA-Human) in the National Genomics Data Center under accession no. HRA004625 (https://ngdc.cncb.ac.cn/gsa-human/browse/HRA004625).
|
| |
|
| Contributor(s) |
Chen D, Zhang S, Fang W |
| Citation(s) |
37612267 |
| |
| Submission date |
Feb 22, 2022 |
| Last update date |
Sep 14, 2023 |
| Contact name |
Dijun Chen |
| E-mail(s) |
dijunchen@nju.edu.cn
|
| Organization name |
Nanjing University
|
| Department |
Life Sciences
|
| Street address |
Xianlin
|
| City |
Nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
310028 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA809328 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE197177_RAW.tar |
656.9 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
| Raw data not provided for this record |
| Processed data provided as supplementary file |
|
|
|
|
 |
Less...
More...