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| Status |
Public on May 23, 2022 |
| Title |
Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptional analysis of human lung epithelial cells indicates a functional link of AhR to barrier protection/inflammatory mediator signaling upon allergen challenge.
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| Overall design |
Primary normal bronchial epithelial cells (NHBEs) were incubated eihter medium or AhR inhibitor CH223191 (1µM/mL) for 2 hours, afterwards with IL-4 (50ng/mL) and house dust mite extract (40µg/mL) for 6 hours.
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| Contributor(s) |
Alessandrini F, de Jong R, Wimmer M, Maier A, Fernandez I, Hils M, Buters J, Biedermann T, Zissler UM, Hoffmann C, Esser-von Bieren J, Schmidt-Weber CB, Ohnmacht C |
| Citation(s) |
35734174 |
| Submission date |
Feb 17, 2022 |
| Last update date |
Jun 30, 2022 |
| Contact name |
Ulrich M Zissler |
| E-mail(s) |
ulrich.zissler@tum.de
|
| Phone |
+49 (0)89 4140 3472
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| Organization name |
Technical University of Munich & Helmholtz Center Munich
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| Department |
Center of Allergy & Environment (ZAUM)
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| Lab |
Airway Immunology
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| Street address |
Biedersteiner Str. 29
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| City |
Munich |
| ZIP/Postal code |
80802 |
| Country |
Germany |
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| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
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| Samples (29)
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| Relations |
| BioProject |
PRJNA808035 |
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