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Series GSE196445 Query DataSets for GSE196445
Status Public on Jan 25, 2024
Title Dyrk1a dosage effects on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using bulk RNAseq
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We performed bulk RNAseq on whole hearts from E13.5 Dp1Tyb embryos and from wild-type littermates, as well as hearts from E13.5 Dp1TybDyrk1a+/+/- embryos and wild-type littermates. Analysis showed the expected increased expression of the Hsa21-orthologous genes on Mmu16 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in Dp1Tyb hearts. Some of these changes were dependent on 3 copies of Dyrk1a.
Overall design RNAseq on 5 E13.5 Dp1Tyb embryonic hearts and 5 wild-type littermate embryonic hearts, and on 5 E13.5 Dp1TybDyrk1a+/+/- embryonic hearts and 5 wild-type littermate embryonic hearts.
Contributor(s) Lana-Elola E, Llorian M, Tybulewicz V
Citation(s) 38266108
Submission date Feb 09, 2022
Last update date Apr 25, 2024
Contact name Victor Tybulewicz
Organization name Francis Crick Institute
Street address 1 Midland Road
City London
ZIP/Postal code NW1 1AT
Country United Kingdom
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (20)
GSM5884345 LAN326A1_S30_L006
GSM5884346 LAN326A11_S6_L003
GSM5884347 LAN326A2_S31_L006
This SubSeries is part of SuperSeries:
GSE196447 Down Syndrome
BioProject PRJNA804913

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE196445_Table_logtransformed_normalized_counts_Dp1TybData.txt.gz 4.5 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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