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Series GSE19567 Query DataSets for GSE19567
Status Public on Dec 19, 2009
Title Imatinib and Nilotinib induced molecular changes in Philadelphia chromosome-positive Chronic Myelogenous Leukemia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Chronic myelogenous leukemia (CML) is a malignant stem cell disease characterized by a reciprocal translocation between chromosome 9 and 22. The selective bcr-abl tyrosine-kinase inhibitor Imatinib has become the therapy of choice for patients with newly diagnosed CML including those previously considered candidates for allogeneic haematopoietic stem cell transplantation. The tyrosine-kinase inhibitor Nilotinib is a derivate of Imatinib with higher potency.
To examine the molecular and functional effects of Nilotinib and Imatinib in chronic myelogenous leukemia, we performed gene expression and functional analyses in K562 cells following treatment with the two tyrosine kinase inhibitors.
Overall design Affymetrix U133A 2.0 microarrays were used to examine the gene expression profile of K562 cells after in vitro treatment with Imatinib (0.5 µM) or Nilotinib (0.05 µM) for 24 hours. Gene expression data of the treated cells were compared with data of untreated cells.
Contributor(s) Bruennert D, Neumann F
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Submission date Dec 18, 2009
Last update date Dec 06, 2018
Contact name Daniela Bruennert
Phone 0211/8114869
Organization name University Clinic Duesseldorf
Department Clinic for Hematology, Oncology and clin. Immunology
Lab Haematologisches Forschungslabor
Street address Universitaetsstr. 1
City Duesseldorf
ZIP/Postal code 40225
Country Germany
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (12)
GSM487683 K562 AMN107 sample 1
GSM487684 K562 AMN107 sample 2
GSM487685 K562 AMN107 sample 3
BioProject PRJNA122473

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19567_RAW.tar 25.8 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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