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| Status |
Public on Jul 09, 2023 |
| Title |
Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity II |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Bulk RNA sequence (RNA-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. 4T1 breast cancer cells were orthotopic injection into Balb/c mice. tumor tissue has been isolated (~ 100 mm3) and total RNA were extracted by Trizol, followed by cDNA were sequenced by Illumina NextSeq 550.
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| Overall design |
Examination of therapeutic modulation of IL10/CSF1R fusion protein within tumor microenvironment in mice cancer model. RNA-seq of tumor tissues from orthotopic cancer tissue after four dose treatments.
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| Contributor(s) |
Chang Y, Yang M |
| Citation(s) |
37586318 |
| |
| Submission date |
Jan 04, 2022 |
| Last update date |
Sep 14, 2023 |
| Contact name |
JuPei Chen |
| E-mail(s) |
pei03231987@nycu.edu.tw
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| Organization name |
National Yang Ming Chiao Tung University
|
| Street address |
No. 155, Sec. 2, Linong St. Beitou Dist.
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| City |
Taipei |
| ZIP/Postal code |
112 |
| Country |
Taiwan |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA794177 |
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