|
| Status |
Public on Jan 07, 2022 |
| Title |
The immunological comparison of control PDA tumors and Krt19-edited PDA tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our studies indicate that cancer cells of carcinomas are coated with CXCL12 chemokine in covalent conjugation with keratin-19 (KRT19). Murine pancreatic ductal adenocarcinomas (PDA) formed with Krt19-edited cancer cells lack the CXCL12-coating and are infiltrated with T cells, compared to tumors formed with control sgScramble PDA cells. To probe the immunological role of this CXCL12-coating thoroughly, bulk RNA sequencing of subcutaneous (s/c) murine sgScramble PDA tumors and Krt19-edited PDA tumors were conducted.
|
| |
|
| Overall design |
sgScramble PDA tumors vs sgKrt19 PDA tumors
|
| |
|
| Contributor(s) |
Wang Z, Fearon DT |
| Citation(s) |
35046049, 38980903 |
| |
| Submission date |
Jan 04, 2022 |
| Last update date |
Aug 16, 2024 |
| Contact name |
Zhikai Wang |
| E-mail(s) |
wang.zhikai.1@gmail.com
|
| Organization name |
Cold Spring Harbor Laboratory
|
| Lab |
Fearon Lab
|
| Street address |
1 Bungtown Road
|
| City |
Cold Spring Harbor |
| State/province |
NY |
| ZIP/Postal code |
11724 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA794150 |
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