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Series GSE19294 Query DataSets for GSE19294
Status Public on Feb 13, 2016
Title Cell type influences metastasis tropism
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We report that the cell of origin plays an important role in this metastatic tropism. Following injection into the arterial circulation of mice, each of the identically transformed cell types gave rise to different metastatic patterns.
Using gene expression analysis, we identified the chemokine receptor CXCR4 as being instrumental in determining the distinct metastatic patterns between skeletal muscle precursor cells and skeletal myoblasts.
 
Overall design 3 independent cell lines of primary human skeletal myoblasts, primary skeletal muscle cell precursors, and each of these cell lines transformed with hTERT, the early region of SV40 encoding T-Ag and t-Ag, and RasG12V
analysis of primary human skeletal myoblasts, primary skeletal muscle cell precursors, and each of these cell lines transformed with hTERT, the early region of SV40 encoding T-Ag and t-Ag, and RasG12V
 
Contributor(s) DiSean K, Hsu DS, Counter CM
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Submission date Dec 03, 2009
Last update date Dec 06, 2018
Contact name David Hsu
E-mail(s) hsu00018@dm.duke.edu
Phone 919-684-1739
Fax 919-668-4777
Organization name Duke University
Department Institute for Genome Sciences and Policy
Street address Rm 2167 CIEMAS Bldg, 101 Science Dr.
City Durham
State/province NC
ZIP/Postal code 27710
Country USA
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (12)
GSM478964 skeletal myoblasts_rep1
GSM478965 skeletal myoblasts_rep2
GSM478966 skeletal myoblasts_rep3
Relations
BioProject PRJNA120875

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19294_RAW.tar 23.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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