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Series GSE192901 Query DataSets for GSE192901
Status Public on Jan 05, 2022
Title Transcriptome sequencing of bristol strain (wild-type), metl-9 KO strain and metl-9 mutation strain upon P.aeruginosa infection
Organism Caenorhabditis elegans
Experiment type Expression profiling by high throughput sequencing
Summary We challenge bristol strain (wild-type), metl-9 KO strain (short as KO, has a 101bp insertion, leads to a truncated protein of 258aa) and metl-9 catalytic-activity mutated strain (short as mut, has N172K, D274G mutations in full-length protein) with P.aeruginosa (P.A14), and observe a discrepant transcriptome pattern between wild-type and KO/mut strains. Plenty of innate immune response genes show different expression patterns upon P.A14 infection between the wild-type strain and KO/mut strain. It indicates the important role of metl-9 and 6mA in worm innate immune response modulation.
Overall design RNA-seq of wild-type, KO or mut strain upon P.A14 infection, or normal condition (OP50).
Contributor(s) Ma C, Guan J, Ding W, Li C
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Submission date Jan 02, 2022
Last update date Jan 06, 2022
Contact name Guan Jialiang
Phone 18800192720
Organization name Peking University
Street address China, Beijing, Haidian district, Peking University, 1000871
City Beijing
State/province Beijing
ZIP/Postal code 100871
Country China
Platforms (1)
GPL30091 DNBSEQ-G400 (Caenorhabditis elegans)
Samples (12)
GSM5768306 wild-type normal condition (OP50)_1
GSM5768307 wild-type normal condition (OP50)_2
GSM5768308 wild-type infected (P.A14)_1
BioProject PRJNA793702

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE192901_RAW.tar 17.9 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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