NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE192767 Query DataSets for GSE192767
Status Public on Apr 24, 2022
Title Expression data from human lymphoblastoid cell lines (LCLs)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The X-linked alpha thalassaemia intellectual disability syndrome (ATRX) protein is a member of the SWI/SNF family of chromatin remodelling factors which acts as an ATP dependent molecular motor. Germline mutations in ATRX give rise to a severe form of syndromal intellectual disability (ATR-X syndrome). To date, only a small number of genes have been identified that are affected by pathogenic ATRX mutations in human.
We performed microarray experiments on LCLs from normal individuals and patients with diverse pathogenic ATRX mutations, to identify more genes regulated by ATRX.
 
Overall design We used 20 LCLs from unaffected individuals and 28 LCLs from patients for RNA extraction and hybridization on Affymetrix microarrays.
 
Contributor(s) Truch J, Repapi E
Citation(s) 35710802
Submission date Dec 29, 2021
Last update date Jun 27, 2022
Contact name Julia Truch
Organization name University of Oxford
Department RDM - WIMM
Lab GIBBONS/HIGGS
Street address John Radcliffe Hospital, Headley Way, Headington
City Oxford
ZIP/Postal code Oxford OX3 9DS
Country United Kingdom
 
Platforms (1)
GPL15207 [PrimeView] Affymetrix Human Gene Expression Array
Samples (48)
GSM5765052 LCL case, biological replicate 1
GSM5765053 LCL case, biological replicate 2
GSM5765054 LCL case, biological replicate 3
Relations
BioProject PRJNA793048

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE192767_RAW.tar 95.5 Mb (http)(custom) TAR (of CEL)
GSE192767_normalized_data_with_controls.txt.gz 18.1 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap