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Series GSE191249 Query DataSets for GSE191249
Status Public on Dec 20, 2021
Title Gene expression analysis of transplanted hiPSC-astrocyte progenitors generated from monozygotic twin pair discordant for schizophrenia into mouse brain
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The humanized mice's frontal cortical tissues were used for transcriptomic analysis, as this brain area shows early involvement in pathophysiology of schizophrenia. We transplanted hiPSC-astrocyte progenitors from one monozygotic twin pair discordant for schizophrenia and one healthy control into neonatal mouse forebrains and analyzed mouse behavior at five and ten months, followed by gene expression profiling of the frontal cortices seven days later.
Overall design Ribo-depleted RNA was sequenced with Illumina Next-seq 500 from transplanted mouse cortical samples
Contributor(s) Koistinaho J, Tiihonen J
Citation(s) 34936134
Submission date Dec 20, 2021
Last update date Mar 28, 2022
Contact name Iiris Hovatta
Organization name University of Helsinki
Department Department of Psychology and Logopedics
Lab Neurogenomics
Street address Haartmaninkatu 3
City Helsinki
ZIP/Postal code 00014
Country Finland
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
Samples (21)
GSM5742187 103_S10
GSM5742188 112_S11
GSM5742189 113_S12
This SubSeries is part of SuperSeries:
GSE191250 Contribution of astrocytes to familial risk and clinical manifestation of Schizophrenia
BioProject PRJNA790754

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Supplementary file Size Download File type/resource
GSE191249_Transplanted_Astro_SZ_hsa.txt.gz 342.8 Kb (ftp)(http) TXT
GSE191249_Transplanted_Astro_SZ_mmu.txt.gz 809.9 Kb (ftp)(http) TXT
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