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| Status |
Public on Dec 20, 2021 |
| Title |
Gene expression analysis of transplanted hiPSC-astrocyte progenitors generated from monozygotic twin pair discordant for schizophrenia into mouse brain |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The humanized mice's frontal cortical tissues were used for transcriptomic analysis, as this brain area shows early involvement in pathophysiology of schizophrenia. We transplanted hiPSC-astrocyte progenitors from one monozygotic twin pair discordant for schizophrenia and one healthy control into neonatal mouse forebrains and analyzed mouse behavior at five and ten months, followed by gene expression profiling of the frontal cortices seven days later.
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| Overall design |
Ribo-depleted RNA was sequenced with Illumina Next-seq 500 from transplanted mouse cortical samples
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| Contributor(s) |
Koistinaho J, Tiihonen J |
| Citation(s) |
34936134 |
| Submission date |
Dec 20, 2021 |
| Last update date |
Mar 28, 2022 |
| Contact name |
Iiris Hovatta |
| E-mail(s) |
iiris.hovatta@helsinki.fi
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| Organization name |
University of Helsinki
|
| Department |
Department of Psychology and Logopedics
|
| Lab |
Neurogenomics
|
| Street address |
Haartmaninkatu 3
|
| City |
Helsinki |
| ZIP/Postal code |
00014 |
| Country |
Finland |
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| Platforms (2) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
| GPL19415 |
Illumina NextSeq 500 (Homo sapiens; Mus musculus) |
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| Samples (21)
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| This SubSeries is part of SuperSeries: |
| GSE191250 |
Contribution of astrocytes to familial risk and clinical manifestation of Schizophrenia |
|
| Relations |
| BioProject |
PRJNA790754 |
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