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Series GSE190457 Query DataSets for GSE190457
Status Public on Dec 31, 2022
Title Chromatin accessibility profiling of B cell subsets
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Terminal B cell differentiation into antibody-secreting cells (ASC) is a critical process for adaptive immune responses. Although many efforts have been made in the recent years to decipher the cellular and molecular events sustaining this differentiation, both in mouse and human models, several key steps still need further elucidation. We used a combined RNA-seq and ATAC-seq approach to decipher the chromatin and gene expression events driving ASC differentiation from naive or memory B cells. Out goal with the dataset was to explore the divergent molecular properties of naive and memory B cells that sustain their differential abilities to differentiate into ASC.
Overall design Four cell populations of peripheral blood and in vitro differentiating B cells were analyzed by ATAC-seq after cell sorting on 50,000 cells. No replicates.
Contributor(s) Chatonnet F, Pignarre A, Caron G, Fest T
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Submission date Dec 08, 2021
Last update date Jan 02, 2023
Contact name Fabrice Chatonnet
Phone +33 2 99 28 99 39
Organization name University Hospital of Rennes
Lab Inserm U1236 MICMAC
Street address 2 rue Henri le Guilloux
City Rennes
ZIP/Postal code 35033
Country France
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (4)
GSM5724092 MBC_IgG ATAC-seq
GSM5724093 MBC_IgM ATAC-seq
GSM5724094 NBC ATAC-seq
This SubSeries is part of SuperSeries:
GSE190458 Expression profiling and chromatin accessibility profiling of B cell subsets
BioProject PRJNA787223

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Supplementary file Size Download File type/resource
GSE190457_RAW.tar 12.6 Gb (http)(custom) TAR (of BW)
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Raw data are available in SRA
Processed data provided as supplementary file

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