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| Status |
Public on Jul 09, 2023 |
| Title |
Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Single cell sequence (SC-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection in C57BL/6 mice. CD45+ immune cells has been isolated, analyzed and sequenced by dropped based scRNA-seq, cDNA were sequenced by Illumina Novaseq 6000.
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| Overall design |
Examination of therapeutic modulation of IL10/CSF1R fusion protein within tumor microenvironment in mice cancer model. SC-seq of CD45+ immune infiltrated cells from orthotopic cancer tissue after four dose treatments.
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| Contributor(s) |
Chang Y, Yang M |
| Citation(s) |
37586318 |
| |
| Submission date |
Dec 03, 2021 |
| Last update date |
Sep 14, 2023 |
| Contact name |
JuPei Chen |
| E-mail(s) |
pei03231987@nycu.edu.tw
|
| Organization name |
National Yang Ming Chiao Tung University
|
| Street address |
No. 155, Sec. 2, Linong St. Beitou Dist.
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| City |
Taipei |
| ZIP/Postal code |
112 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA785881 |
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