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Series GSE188528 Query DataSets for GSE188528
Status Public on Dec 15, 2021
Title Single-cell delineation of lineage and genetic identity in the mouse brain
Organism Mus musculus
Experiment type Other
Summary We used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during murine forebrain development. We found several examples of clonal divergence and convergence in both neurons and glia, and examined the processes that led to clonal divergence of GABAergic neurons. Immediately after exiting the cell-cycle, GABAergic neurons originating from the same mitotic progenitor diverged into different trajectories, suggesting that differentiation into subtypes is initiated as a lineage-dependent processes at the progenitor cell level.
Overall design Transcriptomic and barcode-lineage tracing of developing mouse forebrain cell subtypes
Contributor(s) Mayer C, Bandler RC, Vitali I, Delgado RN
Citation(s) 34912118
Submission date Nov 10, 2021
Last update date Jan 20, 2022
Contact name Christian Mayer
Organization name Max Planck Institute of Neurobiology.
Lab Mayerlab
Street address Am Klopferspitz 18
City Martinsried
ZIP/Postal code 82152
Country Germany
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (63)
GSM5684872 LV12_t: Transcritpomic dataset of STICR-E12 #4
GSM5684873 CA304_t: Transcritpomic dataset of STICR-E14 #4
GSM5684874 CA303_t: Transcritomic dataset of wt LGE E15
BioProject PRJNA779276

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE188528_Processed_LBC_CSV.tar.gz 439.8 Kb (ftp)(http) TAR
GSE188528_RAW.tar 607.5 Mb (http)(custom) TAR (of RDS)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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