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| Status |
Public on Dec 31, 2022 |
| Title |
Histone methyltransferase SETDB1 selectively regulates cortical HTR3A interneuron development and anxiety-like behavior in mice |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
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| Summary |
Histone methyltransferase SETDB1 is critically involved in brain development, but its role in regulating GABAergic interneurons remains unknown. Here, we used RNA-seq and ATAC-seq to study the gene expression and chromatin accessibility in ganglionic eminences (GE) at E15.5 from brain-specific Setdb1 conditional knockout mice (Setdb1-Nestin-cKO) and controls both in vitro and in vivo.
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| Overall design |
ATAC-seq from GE_NPC, 3 animals per genotype; RNA-seq from GE_NPC, 3 animals per genotype; RNA-seq from GE tissue, 2 animals for the control and 3 animals for the Setdb1-Nestin-cKO group.
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| Contributor(s) |
Jiang Y, Zheng S, Li J |
| Citation(s) |
36335068 |
| |
| Submission date |
Oct 29, 2021 |
| Last update date |
Apr 05, 2023 |
| Contact name |
Yan Jiang |
| E-mail(s) |
yan_jiang@fudan.edu.cn
|
| Organization name |
Fudan University
|
| Department |
Institutes of Brain Science
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| Street address |
131 Dongan rd
|
| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
| |
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| Platforms (2) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA776162 |
| SRA |
SRP343727 |
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