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Series GSE186760 Query DataSets for GSE186760
Status Public on Dec 31, 2022
Title Epigenetic profiling of microglia-specific gene transcription and chromatin accessibility in mouse forebrain after chronic mild stress
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Multiple studies have suggested that stress induces neuroinflammation and contributes to emotion-related behavioral deficits. To study epigenetic changes in microglia after chronic stress, we purified microglia from mouse brain after exposure to chronic unexpected mild stress (CUMS), and then performed RNA-seq and ATAC-seq to study microglia-specific alterations of transcriptome and chromatin accessibility in response to chronic stress.
 
Overall design Microglia-specific ATAC-seq and RNA-seq in stress and control mice, 3 animals per group.
 
Contributor(s) Jiang Y, Zhang Y
Citation(s) 36532375
Submission date Oct 28, 2021
Last update date Apr 05, 2023
Contact name Yan Jiang
E-mail(s) yan_jiang@fudan.edu.cn
Organization name Fudan University
Department Institutes of Brain Science
Street address 131 Dongan rd
City Shanghai
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (12)
GSM5660670 RNA_seq_CO1
GSM5660671 RNA_seq_CO2
GSM5660672 RNA_seq_CO3
Relations
BioProject PRJNA775980
SRA SRP343634

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE186760_RAW.tar 515.2 Mb (http)(custom) TAR (of NARROWPEAK, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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