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Series GSE185653 Query DataSets for GSE185653
Status Public on Oct 05, 2022
Title Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary We report that oxidized nicotinamide adenine dinucleotide (NAD+) is indispensable for mouse pre-implantation development. NAD+ could avoids excessive minor zygotic gene activation (ZGA) by cooperating with SIRT1 to remove zygotic H3K27ac. In human, NAD+ supplement can promote the removal of zygotic H3K27ac and benefit pre-implantation development. Our findings demonstrate that precise and timely regulation of minor ZGA is controlled by metabolic dynamics, and enhance our understanding of the metabolism of mammalian early embryos.
 
Overall design Examination of H3K27ac in mouse pre-implantation embryos.
Examination of RNA-seq in mouse pre-implantation embryos.
 
Contributor(s) Li J, Zhang J, Hou W, Gao S, Huang G, Kong Q
Citation(s) 36167681
Submission date Oct 11, 2021
Last update date Oct 05, 2022
Contact name Hou wei bo
Organization name College of Life Science,Northeast Agricultural University
Street address Xiangfang District
City Harbin
State/province Heilongjiang
ZIP/Postal code 150030
Country China
 
Platforms (2)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (42)
GSM5621186 H3K27ac-Sperm-rep1
GSM5621187 H3K27ac-Sperm-rep2
GSM5621188 H3K27ac-MII-rep1
Relations
BioProject PRJNA770284
SRA SRP340833

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE185653_H3K27ac-4-cell-FK866-NMN.bw 30.8 Mb (ftp)(http) BW
GSE185653_H3K27ac-4-cell-FK866.bw 34.2 Mb (ftp)(http) BW
GSE185653_H3K27ac-4-cell.bw 27.9 Mb (ftp)(http) BW
GSE185653_H3K27ac-MII.bw 14.9 Mb (ftp)(http) BW
GSE185653_H3K27ac-Sperm.bw 64.4 Mb (ftp)(http) BW
GSE185653_H3K27ac-Zygote.bw 62.3 Mb (ftp)(http) BW
GSE185653_H3K27ac-early-2-cell.bw 59.5 Mb (ftp)(http) BW
GSE185653_H3K27ac-late-2-cell-FK866-NMN.bw 20.6 Mb (ftp)(http) BW
GSE185653_H3K27ac-late-2-cell-FK866.bw 18.1 Mb (ftp)(http) BW
GSE185653_H3K27ac-late-2-cell-Sirt1.bw 31.8 Mb (ftp)(http) BW
GSE185653_H3K27ac-late-2-cell-TSA.bw 91.1 Mb (ftp)(http) BW
GSE185653_H3K27ac-late-2-cell.bw 28.1 Mb (ftp)(http) BW
GSE185653_RNASeq_counts.txt.gz 599.9 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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