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Series GSE184790 Query DataSets for GSE184790
Status Public on Jun 23, 2022
Title T cell transriptome in chromosome 22q11.2 deletion syndrome
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed transcriptome analysis via RNA sequencing of T cells isolated from participants with and without 22qDS and T cells of 22qDS participants with low or normal number of T cells.
Overall design A single-centered study involving a convenience sample of participants along with retrospective chart review. This IRB approved study included patients referred to a multidisciplinary clinic for management of chromosome 22q11.2 deletion syndrome. Healthy controls were recruited by recruitment announcements in the hospital. Peripheral blood was collected from participants aged 5-8 years. Immune function testing was performed. RNA sequencing was completed on isolated T cells; and differential gene expression profiles of T cells between 22qDS and healthy controls were established.
Contributor(s) Raje N, Noel-MacDonnell JR, Shortt K, Heruth DP
Citation(s) 35940635
Submission date Sep 26, 2021
Last update date Sep 30, 2022
Contact name Daniel Paul Heruth
Phone 8169836502
Organization name Children's Mercy
Department Pediatrics
Street address 4th Floor PRC, 2401 Gillham Road
City Kansas City
State/province MO
ZIP/Postal code 64108
Country USA
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (19)
GSM5597469 S1-Case-N
GSM5597470 S2-Case-N
GSM5597471 S4-Case-L
BioProject PRJNA766425
SRA SRP338763

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE184790_RajeN_RNAseq_22q11.2_FPKM.xlsx 9.0 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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