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Series GSE184790 Query DataSets for GSE184790
Status Public on Jun 23, 2022
Title T cell transriptome in chromosome 22q11.2 deletion syndrome
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed transcriptome analysis via RNA sequencing of T cells isolated from participants with and without 22qDS and T cells of 22qDS participants with low or normal number of T cells.
 
Overall design A single-centered study involving a convenience sample of participants along with retrospective chart review. This IRB approved study included patients referred to a multidisciplinary clinic for management of chromosome 22q11.2 deletion syndrome. Healthy controls were recruited by recruitment announcements in the hospital. Peripheral blood was collected from participants aged 5-8 years. Immune function testing was performed. RNA sequencing was completed on isolated T cells; and differential gene expression profiles of T cells between 22qDS and healthy controls were established.
 
Contributor(s) Raje N, Noel-MacDonnell JR, Shortt K, Heruth DP
Citation(s) 35940635
Submission date Sep 26, 2021
Last update date Sep 30, 2022
Contact name Daniel Paul Heruth
E-mail(s) dpheruth@cmh.edu
Phone 8169836502
Organization name Children's Mercy
Department Pediatrics
Street address 4th Floor PRC, 2401 Gillham Road
City Kansas City
State/province MO
ZIP/Postal code 64108
Country USA
 
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (19)
GSM5597469 S1-Case-N
GSM5597470 S2-Case-N
GSM5597471 S4-Case-L
Relations
BioProject PRJNA766425
SRA SRP338763

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE184790_RajeN_RNAseq_22q11.2_FPKM.xlsx 9.0 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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