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Series GSE184539 Query DataSets for GSE184539
Status Public on Feb 27, 2022
Title Transcriptome analysis of liver tumors derived from human induced liver cancer-forming cells (iLCCs)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We found that a set of six transcription factors, FOXA3, HNF1A, HNF1B, LIN28B, L-MYC, and KLF5, can induce direct conversion of human umbilical vein endothelial cells (HUVECs) into liver cancer-forming cells (LCCs). These induced LCCs (iLCCs) efficiently give rise to tumors that closely resemble human combined hepatocellular cholangiocarcinoma after transplantation to immunodeficient mice. We conducted RNA-seq analyses to investigate the characteristincs of the tumors derived from iLCCs.
 
Overall design RNA-Seq analyses for the tumors derived from iLCCs.
 
Contributor(s) Suzuki A, Ohkawa Y, Horisawa K, Goya T
Citation(s) 35220676
Submission date Sep 21, 2021
Last update date May 29, 2022
Contact name Atsushi Suzuki
Organization name Kyushu University
Department Medical Institute of Bioregulation
Lab Division of Organogenesis and Regeneration
Street address 3-1-1 Maidashi, Higashi-ku
City Fukuoka
State/province Fukuoka
ZIP/Postal code 812-8582
Country Japan
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (2)
GSM5592212 iLCC-derived tumor-1
GSM5592213 iLCC-derived tumor-2
Relations
BioProject PRJNA765004
SRA SRP338086

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE184539_count_matrix.csv.gz 151.6 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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