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Series GSE183617 Query DataSets for GSE183617
Status Public on Apr 24, 2022
Title BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (Cut&Run)
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells.
 
Overall design Cut&Run analysis of 27 samples: Brg1, Arid1a and c-Myc binding sites were analyzed in first division Arid1a KO and WT CD8 T cells; c-Myc KO and WT activated CD8 T cells. 2 replicates for each group.
 
Contributor(s) Guo A, Huang H, Chen MJ, Chi H, Green DR
Citation(s) 35732731
Submission date Sep 07, 2021
Last update date Jul 08, 2022
Contact name Douglas R Green
E-mail(s) douglas.green@stjude.org
Organization name St Jude Children's Research Hospital
Department Immunology
Lab Green lab
Street address 262 Danny Thomas Pl
City Memphis
State/province United States
ZIP/Postal code 38105
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (27)
GSM5563525 Arid1a KO - Arid1a binding replicate 1
GSM5563526 Arid1a KO - Arid1a binding replicate 2
GSM5563527 Arid1a KO - Brg1 binding replicate 1
This SubSeries is part of SuperSeries:
GSE183619 BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells
Relations
BioProject PRJNA761412
SRA SRP336044

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE183617_RAW.tar 4.1 Gb (http)(custom) TAR (of BED, BIGWIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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