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Series GSE18333 Query DataSets for GSE18333
Status Public on May 15, 2010
Title Distinct genomic differences in prostate cancer between Western countries and China
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary The reason why prostate cancer is significantly more common in Western than Asian men is unknown. Using a genome-wide approach to compare the genomic changes in prostate cancer tissues, we determined that those from Chinese patients lack key somatic genomic changes commonly found in Western patients, including the 21q22.2-22.3 deletion which causes the TMPRSS2:ERG fusion gene, and 10q deletion which leads to PTEN inactivation. The results were confirmed and their consequence on ERG expression was identified by study of a large series of Chinese and UK samples using tissue-microarrays. Subsequently, we identified significant AR genotype differences between UK and Chinese prostate cancer patients. The identification of specific somatic genomic differences in cancers from distinct populations may provide an opportunity to identify cancer-causing or protective factors.
Overall design Copy number analysis of Affymetrix SNP 6.0 array was performed for 5 UK and 39 Chinese prostate cancer. Except 6 Chinese samples, all other samples have case-matched normal controls. Unpaired Chinese tumor samples were analyzed against a baseline from 33 Chinese normal prostate samples.
Contributor(s) Mao X, Yu Y, Boyd LK, Xue L, Ren G, Lin D, Chaplin T, Kudahetti SC, Stankiewicz E, Beltran L, Gupta M, Oliver RT, Lemoine NR, Berney DM, Young BD, Lu Y
Citation(s) 20516122
Submission date Sep 29, 2009
Last update date Nov 27, 2018
Contact name Xueying Mao
Organization name Queen Mary
Street address Charterhouse Square
City London
ZIP/Postal code EC1M 6BQ
Country United Kingdom
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (82)
GSM457679 SH1 Chinese prostate cancer
GSM457680 SH1 Chinese normal prostate
GSM457681 SH2 Chinese prostate cancer
BioProject PRJNA117995

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18333_RAW.tar 3.4 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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